Sestola (Sestolese: ; Frignanese: ) is a comune (municipality) in the province of Modena, in the Italian region of Emilia-Romagna, located about southwest of Bologna and about southwest of Modena. It is located near the Monte Cimone and other mountains of the northern Apennines separating Emilia and Tuscany.
Sestola borders the following municipalities: Fanano, Fiumalbo, Lizzano in Belvedere, Montecreto, Montese, Pavullo nel Frignano, Riolunato.