Sessums is an unincorporated community located in Oktibbeha County, Mississippi. Sessums is approximately east-southeast of Starkville and approximately west of Artesia.
Sessums is located on the former Columbus branch of the Mobile and Ohio Railroad. In 1900, the community had a population of 27.
Sessums is named for Colonel Solomon David Sessums, who owned much of the surrounding land. The Sessums family operated a horse track near their home.
The community was once home to a church, school, multiple stores, and a cotton gin.
The community was once known as a dairy center for Oktibbeha County.
A post office operated under the name Sessums from 1876 to 2000.