Sessano del Molise is a comune (municipality) in the Province of Isernia in the Italian region Molise, located about northwest of Campobasso and about northeast of Isernia. As of 31 December 2004, it had a population of 871 and an area of .
Sessano del Molise borders the following municipalities: Carpinone, Chiauci, Civitanova del Sannio, Frosolone, Miranda, Pesche, Pescolanciano.