Serramanna is a comune (municipality) in the Province of Medio Campidano in the Italian region Sardinia, located about northwest of Cagliari and about south of Sanluri. As of 31 December 2004, it had a population of 9,443 and an area of .
Serramanna borders the following municipalities: Nuraminis, Samassi, Sanluri, Serrenti, Villacidro, Villasor.