Serina is a comune (municipality) in the Province of Bergamo in the Italian region of Lombardy, located about northeast of Milan and about northeast of Bergamo. As of 31 December 2004, it had a population of 2,214 and an area of .
The municipality of Serina contains the frazioni (subdivisions, mainly villages and hamlets) Corone, Lepreno, Bagnella, and Valpiana.
Serina borders the following municipalities: Algua, Cornalba, Costa di Serina, Dossena, Oltre il Colle, Roncobello, San Pellegrino Terme.