Sergio Domini (born 11 March 1961 in Udine) is an Italian former professional footballer who played as a midfielder.
He played 5 seasons (130 games, 5 goals) in Serie A for A.S. Roma, A.C. Cesena, S.S. Lazio and Brescia Calcio. He did not make his Serie A debut until the age of 26 after spending his first 8 seasons in the lower leagues.