Sergey Mikhaylov may refer to:
- Sergey Mihaylov (born 1976), Uzbek boxer
- Sergey Mikhailov (politician) (born 1965), Russian politician
- Sergei Mikhailov (businessman) (born 1958), Russian businessman
- Sergei Mikhailov (footballer, born 1963), Russian footballer
- Sergey Mikhaylov (footballer, born 1978), Belarusian footballer
- Sergei Mikhailov (footballer, born 1983), Russian footballer
- Sergei Mikhailov (journalist), Russian journalist, director of TASS 2012âÂÂ2023
See also