Sergei Khoroshun (born June 27, 1980) is a Russian professional ice hockey goaltender playing for Epinal Hockey Club of the FFHG Division 1.
Khoroshun previously played in the Kontinental Hockey League for HC Neftekhimik Nizhnekamsk and Vityaz Chekov. He also played one game for Dinamo-Energija Yekaterinburg in the Russian Superleague. He also played in the Tipsport Liga for HC '05 Banská Bystrica and the Ligue Magnus for Aigles de Nice.