Serena is an unincorporated community and census-designated place in LaSalle County, Illinois, United States. As of the 2020 census, Serena had a population of 129. Serena has a post office with ZIP code 60549. Serena was the residence of Peg McDonnell Breslin, the first woman elected to the Illinois Appellate Court outside Cook County.
Serena is located at . According to the 2021 census gazetteer files, Serena has a total area of , all land.
Serena first appeared as a census designated place in the 2020 U.S. census.
As of the 2020 census there were 129 people, 4 households, and 4 families residing in the CDP. The population density was . There were 59 housing units at an average density of . The racial makeup of the CDP was 89.92% White, 2.33% African American, 0.78% Native American, 2.33% Asian, and 4.65% from two or more races. Hispanic or Latino of any race were 6.20% of the population.