The Seremuk River is a river in Southwest Papua, Indonesia.
The river flows in the southern area of Southwest Papua with predominantly tropical rainforest climate (designated as Af in the Köppen-Geiger climate classification). The annual average temperature in the area is 23 ðC. The warmest month is December, when the average temperature is around 24 ðC, and the coldest is August, at 22 ðC. The average annual rainfall is 4797 mm. The wettest month is June, with an average of 662 mm rainfall, and the driest is October, with 225 mm rainfall.