Sepia appelloefi is a species of cuttlefish native to the northwestern Pacific Ocean, specifically the Tsushima Strait and waters between Kyà «shà « and southern Honshà «, Japan. It lives at a depth of up to 350 m.
Sepia appelloefi grows to a mantle length of 90 mm.
The type specimen was collected near Misaki, Japan and is deposited at the Zoologische Staatssammlung Muenchen.