Senna Comasco is a comune (municipality) in the Province of Como in the Italian region Lombardy, located about north of Milan and about south of Como. As of 31 December 2004, it had a population of 2,995 and an area of .
The municipality of Senna Comasco contains the frazione (subdivision) Navedano.
Senna Comasco borders the following municipalities: Cantù, Capiago Intimiano, Casnate con Bernate, Como, Cucciago.