Seneca High School may refer to various high schools in the United States:
- Seneca High School (Illinois), Seneca, Illinois
- Seneca High School MCA in Louisville, Kentucky
- Seneca High School (New Jersey), Tabernacle Township, New Jersey
- Seneca Vocational High School, Buffalo, New York, U.S., closed in 2006
- Seneca High School (Pennsylvania), Erie, Pennsylvania
- Seneca High School (Missouri), Seneca, Missouri
- Seneca Senior High School, Seneca, South Carolina
See also