Sefro (Sifru in the local dialect) is a comune (municipality) in the Province of Macerata in the Italian region Marche, located about southwest of Ancona and about southwest of Macerata. As of 31 December 2004, it had a population of 453 and an area of .
Sefro borders the following municipalities: Camerino, Fiuminata, Pioraco, Serravalle di Chienti.
Among the churches are: