As-Safira ( / ALA-LC: as-Safërah; Aleppo dialect: Sfëre) is a Syrian city administratively belonging to the Aleppo Governorate. It is the administrative center of the as-Safira District. As Safërah has an altitude of , and a population of 106,382 , making it the 11th largest city per geographical entity in Syria.
Medieval geographer Yaqut al-Hamawi spells the name Asfërah (), not as-Safira (), which indicates that the definite article in the modern spelling is a result of hypercorrection.
As-Safira was known in pre-Islamic times as Sipri. Historians have suggested that the name Sipri may have come from the Akkadian word siparru meaning "bronze", which might indicate that copper was mined and bronze was worked there.
Since ancient times the city has been the distribution point for salt gathered from the nearby Sabkhat al-Jabbul.
The Sfire I Treaty which may contain 8th century BCE evidence of a deity called "Most High."
In the 2024 Operation Dawn of Freedom, it was captured by the Syrian National Army.
As-Safira has a cold semi-arid climate (Köppen climate classification: BSk).