The Second Monem ministry was the twelfth cabinet formed in East Pakistan, the former eastern administrative division of Pakistan. It was constituted under the leadership of Abdul Monem Khan, the governor of East Pakistan, prior to the 1965 East Pakistan Provincial Assembly elections. It remained in office for nearly four years.
After winning the 1965 presidential election, Ayub Khan became the president of Pakistan for a second term. On the same year's Republic Day, Khan took oath as president and Abdul Monem Khan as governor of East Pakistan at the federal capital, Islamabad. After being appointed provincial governor for a second time, Monem returned to the province and announced that a new cabinet would be formed by 18 March. The governor stated that it would be a preliminary cabinet, which would later be converted into a full cabinet after the completion of the forthcoming provincial elections. On 29 March 1965, a five-member provincial cabinet was sworn in under the leadership of governor Monem. After the session of the East Pakistan Provincial Assembly concluded in 21 June, it was announced that the number of cabinet members would be increased to ten. In 15 August, three additional members were inducted into the cabinet. In 13 November, two new members joined the cabinet.
During the 1969 Mass Uprising, Mirza Nurul Huda assumed office as the new provincial governor on 23 March 1969. However, the following day president Khan resigned, and Yahya Khan assumed state power and imposed martial law. He pledged to frame a new constitution and form a new government through elections based on adult franchise.
The cabinet consisted of the following ministers:
The former members and their respective portfolios were as follows: