Second Baptist Church of Wayne, also known as the Wayne Village Baptist Church, is a historic Baptist church located at Wayne in Schuyler County, New York. It was built in 1846, and is a Greek Revival style frame church. It has a temple front and two single story additions dating from 1876 / 1921 and 1972. It features a projecting vestibule and a two-stage, domed bell tower contains the original bell cast in 1846.
It was listed on the National Register of Historic Places in 2014.