Seco Mines is an unincorporated community and census-designated place in Maverick County, Texas, United States. Its population was 572 as of the 2020 census. U.S. Route 277 passes through the community.
According to the U.S. Census Bureau, the community has an area of ; of its area is land, and is water.
Seco Mines first appeared as a census designated place in the 2010 U.S. census.