Sde Nitzan (, lit. Field of (Flower) Buds) is a moshav in the northern Negev desert in Israel. Located twelve kilometres east of Kerem Shalom, 8 km east of Gaza Strip and 35 km west of Beersheba, it falls under the jurisdiction of Eshkol Regional Council. In it had a population of .
The moshav was established in 1973 by immigrants from English speaking countries, with the name being an approximate translation of the name of a Jewish philanthropist named Bloomfield ("Field of Flowers").