Scotts Run is a long 2nd order tributary to Big Sandy Creek in Fayette County, Pennsylvania, United States.
Scotts Run rises about 1 mile southwest of Mt. Washington, and then flows southwest to join Big Sandy Creek about 3 miles north-northeast of Elliottsville.
Scotts Run drains of area, receives about 50.8 in/year of precipitation, has a wetness index of 302.71, and is about 96% forested.