Scopello is a comune (municipality) located in the Valsesia region of the Italian Pennine Alps, administratively in the Province of Vercelli, Piedmont. The municipality covers an area of and ranges in elevation from above sea level. It takes its name from its main centre, the small town of Scopello, which stands on the river Sesia at an elevation of .
Other centres include Casa Pareti, , Frasso, Villabella, and Alpe di Mera. The latter, as the name Alpe suggests, once provided summer pasture for livestock, and today is a winter ski resort.
Scopello borders Boccioleto, Campertogno, Caprile, Crevacuore, Guardabosone, Pettinengo, Pila, Piode, Scopa, Trivero, and Valle San Nicolao.
Scopello belongs to the , a union of various municipalities in the Valsesia. The mayor is Antonella de Regis, since 2023.