Scipio is an unincorporated community and census-designated place (CDP) in Geneva Township, Jennings County, Indiana, United States. As of the 2020 census, Scipio had a population of 197.
Scipio was laid out in 1839 and named for Scipio Africanus.
Scipio is located in northwestern Jennings County at the center of Geneva Township. Indiana State Road 7 passes through the center of the community, leading southeast to North Vernon and northwest to Columbus.
According to the U.S. Census Bureau, the Scipio CDP has a total area of , of which , or 1.74%, are water. Sand Creek, a west-flowing tributary of the East Fork of the White River, forms the northern edge of the CDP.