The Scinde Railway () was one of the pioneering railway companies that operated in Sind during the British Raj between 1855 and 1885.
The Scinde Railway was first established by deed of settlement in March 1855 and incorporated by the Scinde Railway Act 1855 (18 & 19 Vict. c. cxv) in July of that year. The company contracted with the government to construct a line between Karachi and Kotri. The company was granted a 5% return on investment up to a maximum of ã1 million in order to build the 120-mile line. The Karachi-Kotri Railway Line work commenced in April 1858 and on 13 May 1861 succeeded in connecting Karachi to Kotri. This was the first railway line for public use between Karachi and Kotri, a distance of 108 miles (174 km). The company was involved in a number of additional railway line projects, as well as the establishment of the Indus Steam Flotilla along the Indus River and Chenab River. The Scinde Railway Act 1857 (20 & 21 Vict. c. clx) granted it the opportunity to extend its operations. In 1870, the Scinde Railway Company was amalgamated with the Punjab Railway and Delhi Railway companies and renamed as the Scinde, Punjab & Delhi Railway company. This was covered by the Scinde Railway Company's Amalgamation Act 1869 (32 & 33 Vict. c. lxxx).
By the end of 1864 the company owned 31 steam locomotives, 66 coaches and 617 goods wagons.