Sayani Gupta (; born 9 October 1985) is an Indian actress who appears in Hindi films. A graduate of the Film and Television Institute of India, she made her feature film debut in 2012 with Second Marriage Dot Com. She has since appeared in supporting roles in films such as Fan (2016), Jolly LLB 2 (2017) and Article 15 (2019). She essayed the role of a blind Pakistani-Bangladeshi lesbian activist named Khanum in Margarita with a Straw opposite Kalki Koechlin.
Gupta was born on 9 October 1985 in Calcutta (now Kolkata) in West Bengal in a Bengali family. She graduated from the Film and Television Institute of India.
As a singer, she sang "Kahab To" in Article 15. She also served background vocals on most of the Four More Shots Please soundtrack.
In 2026, Gupta made her directorial debut with the short film Aasmani, which she also wrote and produced. The film stars Revathy and follows an elderly woman and her granddaughter, exploring themes of love, ageing and independence.
The project was produced by the Sumitra Gupta Foundation for Arts and One India Stories, with executive producers including Nikkhil Advani and Dia Mirza. The screenplay received multiple international awards prior to its planned festival premiere in 2026.