Highway 381 is a provincial highway in Saskatchewan, Canada. It runs from Highway 80 until the Manitoba border, where it transitions into Provincial Road 547. It is about long.
Highway 381 passes through the village of MacNutt and intersects Highway 8.
Hwy 381 begins at an intersection with Hwy 80, several kilometres north of the town of Churchbridge, with the road continuing west as Township Road 243. It heads east through rural farmland for several kilometres, crossing Range Road 1313, which provides access to the village of Calder just to the north, on its way to pass through the southern part of the village of MacNutt, where it has a junction with Hwy 8 and crosses a former railway line. The highway continues due eastward, leaving the village behind to come to an end at the Manitoba border, with the road continuing east as Manitoba Provincial Road 547 (PR 547). The entire length of Hwy 381 is an unpaved, two-lane gravel road, lying entirely within the Rural Municipality of Churchbridge No. 211.
From west to east: