Santo Trafficante Sr. (May 28, 1886 – August 11, 1954) was a Sicilian-born mobster, and father of the powerful mobster Santo Trafficante Jr.
In 1904 Trafficante came to the United States from Sicily. He gained power as a mobster in Tampa, Florida and ruled the Mafia in Tampa from the 1930s until his death in 1954. Trafficante was heavily involved in the operation of illegal bolita lotteries. During his reign, Trafficante was a well-respected boss with ties to Charles "Lucky" Luciano and Thomas Lucchese.
During the 1940s, Trafficante Sr. maintained a strong alliance with Tommy Lucchese, the boss of the Lucchese crime family in New York City. Lucchese would help train his son Trafficante Jr. in the mafia traditions.
Trafficante died of stomach cancer on August 11, 1954; he was a member of L'Unione Italiana, and he was buried in L'Unione Italiana Cemetery in Ybor City. His son, Santo Trafficante Jr. subsequently took over the crime family.