Santo Stefano a Macerata is a village in Tuscany, central Italy. It is administratively a frazione of the comune of Cascina, province of Pisa. At the 2001 census, its population was 86.
The village is located about from Pisa and from Cascina. The main hamlet of the frazione is called Chiesanuova.
The frazione is home to the European Gravitational Observatory and the Virgo interferometer, one of the few facilities in the world dedicated to the detection and study of gravitational waves.