Santo is an unincorporated community and census designated place (CDP) in Palo Pinto County, Texas, United States. It lies on Farm to Market Road 4, 14 miles south of Palo Pinto, and as of the 2020 census had a population of 347.
The Santo Independent School District serves area students.
Santo first appeared as a census designated place in the 2020 U.S. census.