Santiago Mitre (, ; born 4 December 1980) is an Argentine film director and screenwriter. He was named as a member of the jury of the Critics' Week section of the 2016 Cannes Film Festival. In 2016, Mitre won the Havana Star Prize for Best Director for his film Paulina at the 17th Havana Film Festival New York.
In 2025, Mitre was appointed the jury president of the Progressive Cinema, Freestyle and Grand Public Competition sections at the 20th Rome Film Festival.