Santacruz railway station (station code: STC) is on the Western Line and Harbour Line of Mumbai Suburban Railway, in Maharashtra, India. The station began operations in October 1888. The neighbourhood is Santacruz.
Although Santacruz station was formally opened in 1888, it was a stop on the first regular suburban train service of the BB&CI railway (today's Western Railway), which began on 12 April 1867, between Bombay Backbay and Viraur. Before this, during the Backbay Reclamation scheme of the 1860s, BB&CI was contracted to supply ballast. This would be brought in from Santacruz.
During a move to improve safety and efficiency along the line, power barrier gates were installed for the first time at the Santacruz level crossing in December 1952.