Santa Rosa () is a department in Guatemala. The capital is Cuilapa.
On Saturday 8 March 1913, a magnitude 6.4 earthquake hit Santa Rosa, destroying its department capital, Cuilapa. Both the initial quake and the after shocks destroyed a lot of private homes, and also the cathedral and the prison, leaving behind significant human losses; similar destruction occurred at Barberena, Cerro Redondo, Llano Grande and El Zapote. Fraijanes, Pueblo Nuevo Viñas, Coatepeque and Jalpatagua were also affected. Around Cuilapa, there were landslides and road blockades, and even a long crack was reported at Los Esclavos hill.