Nevado de Santa Isabel () is a shield volcano straddling the boundaries of the Colombian departments of Tolima, Caldas, and Risaralda, being the highest point of the latter. The volcano lies approximately 10 kilometers southwest of the larger Nevado del Ruiz volcano. Santa Isabel is the third highest peak in Los Nevados National Natural Park. It is a relatively flat volcano with three domes of nearly equal elevation.
The volcano is located over the Palestina Fault, that crosscuts the underlying El Bosque Batholith of Eocene age, dated at 49.1 ñ 1.7 Ma.