Santa Helena may refer to:
- Helena of Constantinople, the mother of Emperor Constantine the Great
- Saint Helena, an island in the South Atlantic Ocean
- Santa Helena de Goiás, a municipality in Brazil
- Santa Helena de Minas, a municipality in Brazil
- Santa Helena, Paraná, a municipality in Brazil
- Santa Helena, Santa Catarina, a municipality in Brazil
- Santa Helena, Maranhão, a municipality in Brazil
- Santa Helena del Opón, a town and municipality in Colombia
- Grupo Santa Helena, a group of painters
- Santa Helena Esporte Clube, a Brazilian football (soccer) club
See also