The Santa Fe Trail Scenic and Historic Byway is a National Scenic Byway and Colorado Scenic and Historic Byway located in Prowers, Bent, Otero, and Las Animas counties, Colorado, USA. The byway follows the Santa Fe National Historic Trail through southeastern Colorado and connects to the Santa Fe Trail Scenic Byway in New Mexico at Raton Pass, a National Historic Landmark at elevation . The byway visits Amache National Historic Site and Bent's Old Fort National Historic Site, both National Historic Landmarks, and winds between the Spanish Peaks and Raton Mesa, both National Natural Landmarks.
The byway connects with the Highway of Legends National Scenic Byway at Trinidad.