Santa Fe High School may refer to:
- Santa Fe High School (California), in Santa Fe Springs, California, U.S.
- Santa Fe High School (Florida), in Alachua, Florida, U.S.
- Santa Fe High School (New Mexico), in Santa Fe, New Mexico, U.S.
- Santa Fe High School (Texas), in the Santa Fe Independent School District, Santa Fe, Texas, U.S.
- 2018 Santa Fe High School shooting
- Santa Fe Independent School District
- Edmond Santa Fe High School, in Edmond, Oklahoma, U.S.
See also