Santa Cruz Tayata is a town and municipality in Oaxaca in south-western Mexico. The municipality covers an area of km<sup>2</sup>. It is part of the Tlaxiaco District in the south of the Mixteca Region.
As of the 2010 census, the town (locality), which serves as the municipal seat, had a population of 59 inhabitants, while the municipality had a total population of 608 inhabitants. The municipal seat is the third-smallest in all of Mexico (after Santa MarÃÂa del Rosario and Santa MarÃÂa Nduayaco).