Santa Cruz is a district of the Turrialba canton, in the Cartago province of Costa Rica.
Santa Cruz was created on 14 February 1920 by Decreto 28, having been segregated from Alvarado canton.
Santa Cruz has an area of km<sup>2</sup> and an elevation of metres.
For the 2011 census, Santa Cruz had a population of inhabitants.
The district is covered by the following road routes:
The Guayabo National Monument is located between this district and Santa Teresita district, both in Turrialba canton.
The Turrialba cheese is originally from and produced in this district.