Santa Cruz is a census-designated place (CDP) in Starr County, Texas, United States.
It was formed for the 2010 census with a population of 54. There is a former CDP of the same name (Santa Cruz CDP) that was split prior to the 2010 census into the El Chaparral and Santa Rosa CDPs.
Santa Cruz is located at (26.353689, -98.767615).
Santa Cruz first appeared as a census designated place in the 2010 U.S. census.