Santa Ana is a corregimiento within Panama City, in Panamá District, Panamá Province, Panama
During the 18th century, the numerous fires that destroyed part of Panama City created a demographic boom in the Santa Ana community. Its historic church was moved in 1842. During the 1925 Tenant Movement, the US Army was deployed in Santa Ana to contain the demonstrations.
The Malambo orphanage was founded in 1890 in Santa Ana, and moved to a new location in 1995.