Sant'Elena Sannita is a comune (municipality) in the Province of Isernia in the Italian region Molise, located about west of Campobasso and about east of Isernia.The settlement was formerly inhabited by an Arbëreshë community, who have since assimilated.
Sant'Elena Sannita borders the following municipalities: Bojano, Casalciprano, Frosolone, Macchiagodena, Spinete.