Sant'Angelo Limosano is a comune (municipality) in the Province of Campobasso in the Italian region Molise, located about northwest of Campobasso. As of 31 December 2024, it had a population of 301 and an area of .
Sant'Angelo Limosano borders the following municipalities: Fossalto, Limosano, Lucito, Salcito, San Biase, Trivento.