Sant'Angelo Le Fratte is a town and comune in the province of Potenza, in the Southern Italian region of Basilicata. As of 2011 its population was 1,457.
Located near the border of Campania, Sant'Angelo is bounded by the comuni of Brienza, Caggiano (SA), Polla (SA), Satriano di Lucania, Savoia di Lucania, and Tito. It counts the hamlets (frazioni) of Farisi, Isca, Santa Maria Fellana, and San Vito.