Sant'Andrea del Garigliano is a comune (municipality) in the Province of Frosinone in the Italian region Lazio, located about southeast of Rome and about southeast of Frosinone.
Sant'Andrea del Garigliano borders the following municipalities: Castelforte, Rocca d'Evandro, Sant'Ambrogio sul Garigliano, Sant'Apollinare, Vallemaio.