San Piero Patti (Sicilian: San Pieru Patti) is a comune (municipality) in the Metropolitan City of Messina in the Italian region Sicily, located about east of Palermo and about southwest of Messina.
San Piero Patti borders the following municipalities: Patti, Raccuja, Sant'Angelo di Brolo, Librizzi, Montalbano Elicona.
San Piero Patti was conquered and inhabited by the Arabs until the 11th century, when they were defeated by Roger I of Sicily.