San Miguel de Horcasitas is a municipality in the state of Sonora in north-western Mexico. The municipal seat is at San Miguel de Horcasitas.
The municipal area is 1,768.45 km<sup>2</sup>. The population was in 2020 was 10,729.
Neighboring municipalities are: Rayón to the northeast, Ures to the east, Hermosillo to the south, and Carbó to the northwest.