San Lucas Zoquiapam is a town and municipality in Oaxaca in south-western Mexico. The municipality covers an area of 38.27 km<sup>2</sup>. It is part of the Teotitlán District in the north of the Cañada Region.
As of 2005, the municipality had a total population of 7,384.
In prehispanic times, Zoquiapam was subject to Teococuilco and its patron deity was Coqui Nexo, the "lord of multiplication".