San Lorenzello (Campanian: ) is a comune (municipality) in the Province of Benevento in the Italian region Campania, located northeast of Naples and about northwest of Benevento.
San Lorenzello borders the following municipalities: Castelvenere, Cerreto Sannita, Cusano Mutri, Faicchio, Guardia Sanframondi, San Salvatore Telesino.