The San Leone is a river in the Province of Agrigento, Sicily, Italy. Its main stream is long, and it has a drainage basin of . Its source is in the commune of Santa Elisabetta and it empties into the Mediterranean Sea in San Leone, a frazione of the city of Agrigento. It has various names along its course: at its source it is called Akragas, further downstream Drago, then Sant'Anna (the ancient Hypsas) and the final 3 km until its mouth San Leone. Its largest tributary is the San Biagio (also: San Benedetto). In the 19th century it was known as Fiume di Girgenti.