San Giovanni al Natisone () is a (municipality) in the Regional decentralization entity of Udine in the Italian region of Friuli-Venezia Giulia, located about northwest of Trieste and about southeast of Udine.
San Giovanni al Natisone borders the following municipalities: Chiopris-Viscone, Cormons, Corno di Rosazzo, Manzano, Trivignano Udinese.