San Damiano Macra (; ) is a (municipality) in the Province of Cuneo in the Italian region of Piedmont, located about southwest of Turin and about northwest of Cuneo.
San Damiano Macra borders the following municipalities: Cartignano, Castelmagno, Celle di Macra, Dronero, Frassino, Macra, Melle, Roccabruna, and Sampeyre.
In 1716 it merged with Pagliero. In 1929, the municipalities of Lottulo, Pagliero and Paglieres were joined to San Damiano.